Osteoarthritis (OA)Rheumatoid Arthritis (RA)
Degenerative disease that causes articular cartilage loss and joint space narrowing.Autoimmune disease that causes inflammatory synovitis.
Heberden's nodes are bony prominences located at the distal interphalangeal (DIP) joints. Bouchard's nodes are located at the proximal interphalangeal (PIP) joints.Heberden's nodes are absent. Bouchard's nodes are not common, but may be present.
Typically affects joint asymmetrically.Typically affects joints symmetrically.
Usually negative/normal lab findings.Positive rheumatoid factor, anti-CCP antibody, and elevated ESR and CRP.
Radiograph: subchondral sclerosis, osteophytes, cysts, joint space narrowing, subluxation.Radiograph: periarticular osteopenia, bone erosions, joint space narrowing, subluxation.